Phosphodiesterases (PDEs) are key enzymes involved in the regulation of intracellular cyclic nucleotide metabolism. The aim of the present study was to identify and to characterize the PDE isoenzymes present in the human detrusor smooth muscle. Human detrusor PDE isoenzymes were separated by Q-Sepha
Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Detrusor Smooth Muscle: II. Effect of Various PDE Inhibitors on Smooth Muscle Tone and Cyclic Nucleotide Levels In Vitro
β Scribed by Truss, M.C.; Uckert, S.; Stief, C.G.; Forssmann, W.G.; Jonas, U.
- Book ID
- 123000708
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1998
- Tongue
- English
- Weight
- 124 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0022-5347
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Phosphodiesterases (PDEs) regulate intracellular cyclic nucleotide metabolism and, thus, contraction and relaxation of smooth musculature. The aim of the present study was to evaluate the functional effects of isoenzyme-selective inhibitors and their effects on cyclic nucleotide levels in the human
The cyclic nucleotides cyclic adenosine monophosphate (CAMP) and cyclic guanosine monophosphate (cGMP) are second messengers involved in the regulation of contractility in various smooth muscle organs including detrusor smooth muscle. They are synthesized by activation of adenylate and guanylate cyc