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Cyclic Nucleotide Phosphodiesterase (PDE) Isoenzymes in the Human Detrusor Smooth Muscle: II. Effect of Various PDE Inhibitors on Smooth Muscle Tone and Cyclic Nucleotide Levels In Vitro

✍ Scribed by Truss, M.C.; Uckert, S.; Stief, C.G.; Forssmann, W.G.; Jonas, U.


Book ID
123000708
Publisher
Lippincott Williams and Wilkins
Year
1998
Tongue
English
Weight
124 KB
Volume
159
Category
Article
ISSN
0022-5347

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πŸ“œ SIMILAR VOLUMES


Cyclic nucleotide phosphodiesterase (PDE
✍ Truss, M. C. ;οΏ½ckert, S. ;Stief, C. G. ;Kuczyk, M. ;Jonas, U. πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 575 KB

Phosphodiesterases (PDEs) are key enzymes involved in the regulation of intracellular cyclic nucleotide metabolism. The aim of the present study was to identify and to characterize the PDE isoenzymes present in the human detrusor smooth muscle. Human detrusor PDE isoenzymes were separated by Q-Sepha

Cyclic nucleotide phosphodiesterase (PDE
✍ Truss, M. C. ;οΏ½ckert, S. ;Stief, C. G. ;Forssmann, W. G. ;Jonas, U. πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 585 KB

Phosphodiesterases (PDEs) regulate intracellular cyclic nucleotide metabolism and, thus, contraction and relaxation of smooth musculature. The aim of the present study was to evaluate the functional effects of isoenzyme-selective inhibitors and their effects on cyclic nucleotide levels in the human

Effects of various phosphodiesterase-inh
✍ Michael C. Truss; Stefan Ückert; Christian G. Stief; Markus Kuczyk; Peter Schulz πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 744 KB

The cyclic nucleotides cyclic adenosine monophosphate (CAMP) and cyclic guanosine monophosphate (cGMP) are second messengers involved in the regulation of contractility in various smooth muscle organs including detrusor smooth muscle. They are synthesized by activation of adenylate and guanylate cyc