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Cyclic nucleotide analogs as probes of signaling pathways

โœ Scribed by Poppe, Heiko; Rybalkin, Sergei D; Rehmann, Holger; Hinds, Thomas R; Tang, Xiao-Bo; Christensen, Anne E; Schwede, Frank; Genieser, Hans-Gottfried; Bos, Johannes L; Doskeland, Stein O


Book ID
109935959
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
98 KB
Volume
5
Category
Article
ISSN
1552-4450

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Mesoionic xanthine analogs as inhibitors
โœ R. A. Glennon; M. E. Rogers; R. G. Bass; S. B. Ryan ๐Ÿ“‚ Article ๐Ÿ“… 1978 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 383 KB

Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo[3,2-alpha]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-alpha]pyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrate