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Mesoionic xanthine analogs as inhibitors of cyclic AMP phosphodiesterase

✍ Scribed by R. A. Glennon; M. E. Rogers; R. G. Bass; S. B. Ryan

Book ID
102408008
Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
383 KB
Volume
67
Category
Article
ISSN
0022-3549

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✦ Synopsis

Several derivatives of two mesoionic xanthine analogs, mesoionic thiazolo[3,2-alpha]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-alpha]pyrimidine-5,7-diones, were synthesized and evaluated as inhibitors of cyclic AMP phosphodiesterase. A significant number of these compounds demonstrated theophylline-like activity.

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The inhibition by xanthine phosphodieste
The inhibition by xanthine phosphodiesterase inhibitors of the induction of alkaline phosphatase activity in HeLa cells: Relationship of enzyme activity to cyclic AMP concentrations
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## Abstract The three xanthine derivatives, caffeine, theophylline and 3‐isobutyl‐1‐methyl‐xanthine (IBMX) produced dose‐dependent increases in cyclic AMP concentrations in HeLa cells after long term treatment. Only IBMX produced increases over the first 60 minutes, with a peak of approximately 5‐f