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Effect of cyclic AMP, db-cyclic AMP and phosphodiesterase inhibitors on histamine inhibition of the contractile response of the mouse vas deferens

✍ Scribed by M. M. Vohra

Publisher
SP Birkhäuser Verlag Basel
Year
1984
Tongue
English
Weight
652 KB
Volume
14
Category
Article
ISSN
1420-908X

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✍ Walker Wharton; Barry Goz 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 681 KB

## Abstract The three xanthine derivatives, caffeine, theophylline and 3‐isobutyl‐1‐methyl‐xanthine (IBMX) produced dose‐dependent increases in cyclic AMP concentrations in HeLa cells after long term treatment. Only IBMX produced increases over the first 60 minutes, with a peak of approximately 5‐f