Current Protocols in Toxicology || Measurements of Flavin-Containing Monooxygenase (FMO) Activities
โ Scribed by Maines, Mahin D.; Costa, Lucio G.; Hodgson, Ernest; Reed, Donald J.; Sipes, I. Glenn
- Book ID
- 121828122
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2002
- Tongue
- English
- Weight
- 148 KB
- Volume
- 13
- Category
- Article
- ISBN-13
- 9780471140856
- ISSN
- 1934-9254
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Hepatic flavin-containing monooxygenase (FMO) activity of microsomes from adult CD-1, Swiss-Webster, C57BL/6, and DBA/2 mice was found to be significantly higher in females than in males. Based on protein and mRNA levels in CD-1 mice, FMO forms responsible for the gender difference in FMO activity w
Mammalian flavin-containing monooxygenases are known to oxygenate prochiral sulfides often with a high degree of stereoselectivity. In the present study we used two homologous series of n-alkyl aryl sulfides, Ar-S-(CH2)nH, (where Ar=p-tolyl or 2-naphthyl and n=l-7), to probe the active site topograp