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Current Protocols in Cytometry || Assessment of Histone Acetylation Levels in Relation to Cell Cycle Phase

✍ Scribed by Robinson, J. Paul; Darzynkiewicz, Zbigniew; Dobrucki, Jurek; Hyun, William C.; Nolan, John P.; Orfao, Alberto; Rabinovitch, Peter S.

Book ID: 119997723
Publisher: Wiley (John Wiley & Sons)
Year: 2008
Tongue: English
Weight: 169 KB
Volume: 46
Category: Article
ISBN-13: 9780471142959
ISSN: 1934-9297
DOI: 10.1002/0471142956.cy0735s46

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D