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Assessment of ATM phosphorylation on Ser-1981 induced by DNA topoisomerase I and II inhibitors in relation to Ser-139-histone H2AX phosphorylation, cell cycle phase, and apoptosis

✍ Scribed by Akira Kurose; Toshiki Tanaka; Xuan Huang; H. Dorota Halicka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 558 KB
Volume: 68A
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.a.20186

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D