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Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: Relationship to cell-cycle phase and apoptosis

✍ Scribed by Xuan Huang; Akira Kurose; Toshiki Tanaka; Frank Traganos; Wei Dai; Zbigniew Darzynkiewicz


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
306 KB
Volume
69A
Category
Article
ISSN
0196-4763

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D