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Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase

✍ Scribed by Hong Zhao; Frank Traganos; Zbigniew Darzynkiewicz


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
649 KB
Volume
73A
Category
Article
ISSN
0196-4763

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## Abstract ## Background: DNA replication stress often induces DNA damage. The antitumor drug hydroxyurea (HU), a potent inhibitor of ribonucleotide reductase that halts DNA replication through its effects on cellular deoxynucleotide pools, was shown to damage DNA inducing double‐strand breaks (D