Culture adaptation of embryonic stem cells echoes germ cell malignancy
β Scribed by Neil J Harrison; Duncan Baker; Peter W Andrews
- Book ID
- 108785334
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 563 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0105-6263
No coin nor oath required. For personal study only.
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## Abstract Human embryonic stem cells (hESCs) during longβterm culture acquire chromosomal changes similar to those occurring in tumorigenesis. This was raised concerns about the progression from hESCs to malignant cells. This study aimed to investigate the changes in chromosomes, cell phenotype,
## Abstract Embryonic stem cell (ESC) technology provides attractive perspectives for generating unlimited numbers of somatic cells for disease modeling and compound screening. A key prerequisite for these industrial applications are standardized and automated systems suitable for stem cell process