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CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

✍ Scribed by Protul Shrikant; Alexander Khoruts; Matthew F Mescher

Book ID
117722552
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
158 KB
Volume
11
Category
Article
ISSN
1074-7613

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## Abstract Spontaneous tumors frequently express antigens that can be recognized by the immune system but nevertheless manage to evade immune surveillance. To better understand the mechanism of evasion, we followed CD8 and CD4 T cells reacting against a subcutaneously growing tumor, modified to ex