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Recognition and Lysis of Human Melanoma by a CD3+, CD4+, CD8−T-Cell Clone Restricted by HLA-A2

✍ Scribed by Timothy L. Darrow; Zeinab Abdel-Wahab; Mary Ann Quinn-Allen; Hilliard F. Seigler


Book ID
112239613
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
138 KB
Volume
172
Category
Article
ISSN
0008-8749

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## Abstract CD4^+^ Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4^+^ Th cell clone (Th35‐1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic