T cell lines and clones specific for human myelin basic protein (BP) were selected from three multiple sclerosis (MS) patients and two healthy subjects and tested for their proliferative responses to a battery of synthetic peptides, 9 to 21 amino acid residues long. The combined amino acid sequence
CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity
β Scribed by A. Salmaggi; L. Mantia; C. Milanese; G. Bianchi; M. Eoli; A. Campi; A. Nespolo
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 416 KB
- Volume
- 236
- Category
- Article
- ISSN
- 0340-5354
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π SIMILAR VOLUMES
In order to explore the T-cell repertoire to myelin basic protein (BP) of both multiple sclerosis (MS) patients and healthy subjects (HS), we raised BP reactive T-cell lines from blood mononuclear cells of eight MS patients and five HS. These lines were triggered in vitro by human BP. When analyzing
## Abstract Predictors and laboratory correlates of the response of patients with multiple sclerosis to glucocorticoids are not well defined. Our study was undertaken to determine if the levels of myelin basic protein (MBP)βlike material in cerebrospinal fluid (CSF) might indicate which patients wi