Cerebrospinal fluid and peripheral blood T-lymphocyte subsets in multiple sclerosis: monoclonal antibody analysis and correlations with clinical activity
β Scribed by A. Salmaggi; G. Bianchi; D. Cerrato; M. Lazzaroni; L. Malesani; A. Nespolo; F. Corridori; L. La Mantia; C. Milanese
- Publisher
- Springer Milan
- Year
- 1987
- Tongue
- English
- Weight
- 335 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1590-1874
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The cerebrospinal fluid (CSF) represents an important source of T lymphocytes that could be involved in the inflammatory response occurring in the central nervous system in multiple sclerosis (MS). In order to investigate whether the Vbeta gene usage of CSF T lymphocytes is restricted, we analyzed t
## Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, and it is considered to be a T helper 1 (Th1) cellβmediated autoimmune disease. Tβbet has been identified as a key transcription factor for the development of Th1 cells and the inducti