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Common T-cell receptor Vβ usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis

✍ Scribed by Soon Jin Lee; Kai W. Wucherpfennig; Staley A. Brod; Deborah Benjamin; Howard L. Weiner; Dr David A. Hafler


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
814 KB
Volume
29
Category
Article
ISSN
0364-5134

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The cerebrospinal fluid (CSF) represents an important source of T lymphocytes that could be involved in the inflammatory response occurring in the central nervous system in multiple sclerosis (MS). In order to investigate whether the Vbeta gene usage of CSF T lymphocytes is restricted, we analyzed t