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Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA

✍ Scribed by Yang, Wei; Obmolova, Galina; Ban, Changill; Hsieh, Peggy


Book ID
109771172
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
745 KB
Volume
407
Category
Article
ISSN
0028-0836

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5