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Crystal Structure of the Potent Natural Product Inhibitor Balanol in Complex with the Catalytic Subunit of cAMP-Dependent Protein Kinase †

✍ Scribed by Narayana, Narendra; Diller, Thomas C.; Koide, Kazunori; Bunnage, Mark E.; Nicolaou, K. C.; Brunton, Laurence L.; Xuong, Nguyen-Huu; Ten Eyck, Lynn F.; Taylor, Susan S.


Book ID
127151802
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
169 KB
Volume
38
Category
Article
ISSN
0006-2960

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## Abstract The active site of the mammalian cAMP‐dependent protein kinase catalytic subunit (C‐subunit) has a cluster of nonconserved acidic residues—Glu127, Glu170, Glu203, Glu230, and Asp241—that are crucial for substrate recognition and binding. Studies have shown that the Glu230 to Gln mutant