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Crystal structure of the human angiotensin-converting enzyme–lisinopril complex

✍ Scribed by Natesh, Ramanathan; Schwager, Sylva L. U.; Sturrock, Edward D.; Acharya, K. Ravi

Book ID
109890843
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
863 KB
Volume
421
Category
Article
ISSN
0028-0836

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✍ S. Rimar; C.N. Gillis 📂 Article 📅 1992 🏛 Elsevier 🌐 English ⚖ 502 KB

Lisinopril is a potent competitive inhibitor of purified rabbit lung ACE (dissociation t1/2 = 105 min). To examine reversibility of binding and ACE functional activity in situ, the single-pass extraction (E) of an 125I-lisinopril analogue (351A) and the hydrolysis of an ACE substrate, benz-phe-ala-p