Crystal-state 3D-structural characterization of novel 310-helical peptides
✍ Scribed by Dr Marco Crisma; Alessandro Moretto; Mario Rainaldi; Fernando Formaggio; Quirinus B. Broxterman; Bernard Kaptein; Claudio Toniolo
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 244 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1075-2617
- DOI
- 10.1002/psc.482
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## Abstract The crystal and molecular structure of the pentapeptide Boc‐D‐Ala‐ΔPhe‐Gly‐ΔPhe‐D‐Ala‐OMe, containing two dehydrophenylalanine residues, was determined by x‐ray diffraction. The molecule crystallizes in the orthorombic P2~1~2~1~2~1~ space group, with __a__ = 10.439(3), __b__ = 15.319(3)
Highly specific peptide structures can be designed by inserting dehydro residues into peptide sequences. The peptide N-Boc-L-Phe-dehydro-Phe-L-Val-L-Phe-dehydro-Phe-~-V~-OCH~, synthesized by conventional procedures, crystallizes from methanol-water mixtures at 4°C in the tetragonal space group P43 w
## Abstract Four diastereomeric‐Leu‐Leu‐Aib‐Leu‐Leu‐Aib‐peptides, Boc‐D‐Leu‐L‐Leu‐Aib‐L‐Leu‐L‐Leu‐Aib‐OMe (1), Boc‐L‐Leu‐D‐Leu‐Aib‐L‐Leu‐L‐Leu‐Aib‐OMe (2), Boc‐L‐Leu‐L‐Leu‐Aib‐D‐Leu‐L‐Leu‐Aib‐OMe (3), and Boc‐L‐Leu‐L‐Leu‐Aib‐L‐Leu‐D‐Leu‐Aib‐OMe (4), were synthesized. The crystals of the four hexape
## Abstract Single crystals of a novel organic material, 4‐Chloro‐3‐Nitrobenzophenone (4C3N) were grown from acetone solution employing the technique of controlled evaporation. 4C3N belongs to the Orthorhombic system, with a = 12.9665(11) Å, b = 7.4388(6) Å, c = 24.336(2) Å, α = β = γ = 90°. FT‐IR