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CRTAM: A molecule involved in epithelial cell adhesion

✍ Scribed by Erika Garay; Genaro Patiño-López; Socorro Islas; Lourdes Alarcón; Elsy Canche-Pool; Ricardo Valle-Rios; Oscar Medina-Contreras; Giovana Granados; Bibiana Chávez-Munguía; Eusebio Juaristi; Vianney Ortiz-Navarrete; Lorenza González-Mariscal

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
653 KB
Volume
111
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

__C__lass I‐__r__estricted T cell __a__ssociated __m__olecule (CRTAM) is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin‐like proteins. Here we demonstrate for the first time, that CRTAM is expressed in epithelial cells along the lateral membrane and is important for early cell–cell contacts and cell–substrate interactions. CRTAM is sensitive to intermediate filament disruption and treatment of monolayers with soluble CRTAM enhances cell–cell dissociation and lowers transepithelial electrical resistance. Incubation of newly plated cells with anti‐CRTAM antibody decreases the formation of cell aggregates and promotes cell detachment. Co‐cultures of epithelial cells and fibroblasts that lack CRTAM expression and in vitro binding assays, demonstrate the participation of CRTAM in homotypic and heterotypic trans‐interactions. Hence we conclude that CRTAM is a molecule involved in epithelial cell adhesion. J. Cell. Biochem. 111: 111–122, 2010. © 2010 Wiley‐Liss, Inc.

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