✦ LIBER ✦

Cell-cell adhesion molecules in Dictyostelium

✍ Scribed by Chi-Hung Siu

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 793 KB
Volume: 12
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950120802

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✦ Synopsis

Multicellularity in the cellular slime mold Dictyostelium discoideum is achieved by the expression of two types of cell-cell adhesion sites. The EDTA-sensitive adhesion sites are expressed very early in the developmental cycle and a surface glycoprotein of 24000Da is known to be responsible for these sites. The EDTA-resistant contact sites begin to accumulate on the cell surface at the aggregation stage of development. Several glycoproteins have been implicated in the EDTA-resistant type of cell-cell binding and the best characterized one has an M,. of 80 000 (gp80). gp80 mediates cell-cell binding via homophilic interaction and its cell binding site has been mapped to an octapeptide sequence. The mechanism by which gp80 mediates cell-cell adhesion will be discussed.

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