Crown nucleoside monophosphate diesters: a new class of nucleoside prodrugs
β Scribed by Gregory T. Morin; Bradley D. Smith
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 240 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Recent studies from this laboratory have shown that 6,5'-cyclopyrlmidine nucleosides2, for example the isopropylideneuridine analogue 1, are very susceptible to oxidation at C-5'. Thus, autoxidation3 of 1. with 02-NaOH, or treatment with Mn02 in methanol readily affords the 5'-ketonucleoside 4. The
Some attempts to obtain a more simple crystalline derivative containing o heavy atom and suitable for the analysis were unsuccessful. Reduction with lithium aluminum deuteride afforded bisdeoxo N-methylcycloshowdomycin acetonide-d4. The details was read by one of us, Tsukudo at the 20th Annual Meeti
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