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Isoxazolidine analogues of pseudouridine: a new class of modified nucleosides

โœ Scribed by Ugo Chiacchio; Antonino Corsaro; Juan Mates; Pedro Merino; Anna Piperno; Antonio Rescifina; Giovanni Romeo; Roberto Romeo; Tomas Tejero


Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
128 KB
Volume
59
Category
Article
ISSN
0040-4020

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An alternative synthesis of the modified RNA nucleoside pseudouridine is reported. This procedure employs coupling of an iodinated pyrimidine and a suitably protected lactone. The resulting hemiacetal is reduced and deprotected to yield pseudouridine.

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