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A practical synthesis of the modified RNA nucleoside pseudouridine

✍ Scribed by Patrick J. Grohar; Christine S. Chow

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
230 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

An alternative synthesis of the modified RNA nucleoside pseudouridine is reported. This procedure employs coupling of an iodinated pyrimidine and a suitably protected lactone. The resulting hemiacetal is reduced and deprotected to yield pseudouridine.

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