Cre-ating Somatic Cell Genetic Mosaics in the Mouse
β Scribed by Todd E. Anthony; Nathaniel Heintz
- Book ID
- 116352620
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 43 KB
- Volume
- 121
- Category
- Article
- ISSN
- 0092-8674
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The determination of gene linkage in the laboratory mouse was approached through somatic cell techniques. Cells of an established line of Chinese hamster lung fibroblasts, Eβ36, were fused with a population of mouse macrophages obtained from the AHe/J inbred strain. A total of 62 primar
The inherited deficiency of galactosylceramide pgalactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid co