Craniofacial resection for tumors of the nasal cavity and paranasal sinuses: A 25-year experience

✍ Scribed by David J. Howard; Valerie J. Lund; William I. Wei

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 209 KB
• Volume: 28
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.20432

✦ Synopsis

Background:

Craniofacial resection is the established "gold standard" for surgical treatment of tumors affecting the anterior skull base.

Methods:

This study analyzed 308 patients (220 males, 88 females) who had undergone craniofacial resection for sinonasal neoplasia with up to 25-year follow-up.

Results:

An overall actuarial survival of 65% at 5 years and 47% at 10 years was found for the cohort as a whole. for patients with malignant tumors, the 5-year actuarial survival was 59%, falling to 40% at 10 years. for patients with benign pathology, the actuarial survival was 92% at 5 years falling to 82% at 10 years. statistical analysis again identified brain involvement, type of malignancy, and orbital involvement as the 3 most significant prognostic factors.

Conclusion:

Analysis of one of the largest single institution cohorts over a 25-year period provides a baseline against which other approaches such as an entirely endoscopic skull base resection must be judged.