Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses : A single institution experience
✍ Scribed by Akihiro Homma; Nobuhiko Oridate; Fumiyuki Suzuki; Shigenari Taki; Takeshi Asano; Daisuke Yoshida; Rikiya Onimaru; Takeshi Nishioka; Hiroki Shirato; Satoshi Fukuda
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 287 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Abstract
BACKGROUND:
The current study aimed to evaluate the efficacy of superselective high‐dose cisplatin infusion with concomitant radiotherapy (RADPLAT) for previously untreated patients with advanced cancer of the nasal cavity and paranasal sinuses.
METHODS:
Between October 1999 and December 2006, 47 patients were given superselective intra‐arterial infusions of cisplatin (100‐120 mg/m^2^ per week) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional external‐beam radiotherapy (65‐70 grays).
RESULTS:
There were 7 patients (14.9%) diagnosed with T3, 22 (46.8%) with T4a, and 18 (38.3%) with T4b disease. During the median follow‐up period of 4.6 years, the 5‐year local progression‐free survival rate was 78.4% for all patients (n = 47), 69.0% for patients with T4b disease (n = 18), and 83.2% for patients with
CONCLUSIONS:
Although a single institution experience, the results of the current study suggest that RADPLAT can cure the majority of patients with advanced cancer of the nasal cavity and paranasal sinuses, as well as preserve organs. Late adverse reactions should be monitored in future studies. Cancer 2009. © 2009 American Cancer Society.