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CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells

✍ Scribed by Susana Gamen; Isabel Marzo; Alberto Anel; Andrés Piñeiro; Javier Naval

Book ID
115932610
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
538 KB
Volume
390
Category
Article
ISSN
0014-5793

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Apoptosis induced by effector cells of the immune system or by cytotoxic drugs is a main mechanism mediating the prevention or elimination of tumoral cells. For instance, the human T-cell leukemia Jurkat is sensitive to Fas-induced apoptosis and to activation-induced cell death (AICD), and the promo