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COX-2 regulates p53 activity and inhibits DNA damage-induced apoptosis

✍ Scribed by Eun-Mi Choi; Jee-In Heo; Jin-Young Oh; Young-Myeong Kim; Kwon-Soo Ha; Jong-Il Kim; Jeong A. Han


Book ID
116289940
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
472 KB
Volume
328
Category
Article
ISSN
0006-291X

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or overexpression of the Max-Planck-Institute for Biochemistry negative regulator Mdm2 (Freedman et al., 1999). For Am Klopferspitz 18a those tumors that retain functional p53 but have ampli-D 82152 Martinsried fication of Mdm2, therapeutic strategies have been Germany developed to inhibit Mdm2, whe