or overexpression of the Max-Planck-Institute for Biochemistry negative regulator Mdm2 (Freedman et al., 1999). For Am Klopferspitz 18a those tumors that retain functional p53 but have ampli-D 82152 Martinsried fication of Mdm2, therapeutic strategies have been Germany developed to inhibit Mdm2, whe
✦ LIBER ✦
Translational Repression of C. elegans p53 by GLD-1 Regulates DNA Damage-Induced Apoptosis
✍ Scribed by Björn Schumacher; Momoyo Hanazawa; Min-Ho Lee; Sudhir Nayak; Katrin Volkmann; Randall Hofmann; Michael Hengartner; Tim Schedl; Anton Gartner
- Book ID
- 116352471
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 728 KB
- Volume
- 120
- Category
- Article
- ISSN
- 0092-8674
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## Abstract DNA damage is known to be an initiator of neuronal death in neurodegenerative conditions such as Parkinson's and Alzheimer's diseases. The mechanism linking DNA damage and neuronal death is not completely understood. Here, we delineate the mechanism by which neuronal death evoked by DNA