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COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages

โœ Scribed by Yevgeniya Bezugla; Angelika Kolada; Sabine Kamionka; Brigitte Bernard; Roland Scheibe; Peter Dieter


Book ID
113864961
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
254 KB
Volume
79
Category
Article
ISSN
0090-6980

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## Abstract Corticotropinโ€releasing factor (CRF), the principal regulator of the hypothalamusโ€pituitaryโ€adrenal (HPA) axis, also modulates the inflammatory response directly, via its effect on mast cells and macrophages. On macrophages, it augments production of lipopolysaccharide (LPS)โ€induced pro