Effect of retinoids on LPS-induced COX-2 expression and COX-2 associated PGE2 release from mouse peritoneal macrophages and TNF-α release from rat peripheral blood mononuclear cells

Corticotropin releasing factor receptor

Corticotropin releasing factor receptor 1 (CRF1) and CRF2 agonists exert an anti-inflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-α release from macrophages via induction of COX-2 and PGE2

✍ Christos Tsatsanis; Ariadne Androulidaki; Erini Dermitzaki; Achille Gravanis; An 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract Corticotropin‐releasing factor (CRF), the principal regulator of the hypothalamus‐pituitary‐adrenal (HPA) axis, also modulates the inflammatory response directly, via its effect on mast cells and macrophages. On macrophages, it augments production of lipopolysaccharide (LPS)‐induced pro