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674 Interleukin-1β Induces COX-2 in Colonic Fibroblasts: Roles of Paracrine Amphiregulin and Autocrine PGE2

✍ Scribed by Reba Mustafi; Hongyan Zhu; Apameh Pezeshk; Hardik B. Shah; Zhiqun Song; Loren J. Joseph; Maria Sibilia; Alessandro Fichera; Marc Bissonnette

Book ID: 119430326
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 55 KB
Volume: 136
Category: Article
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(09)60469-8

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## Abstract ## Objective To elucidate the mechanism of basic calcium phosphate (BCP) crystal–induced prostaglandin E~2~ (PGE~2~) production in human foreskin fibroblasts (HFFs), to identify the signaling pathway involved in the induction of cyclooxygenase 2 (COX‐2) messenger RNA (mRNA) by BCP crys