✦ LIBER ✦

Cover Picture: Eur. J. Immunol. 5/09

✍ Scribed by Franco Scaldaferri; Miquel Sans; Stefania Vetrano; Carmen Correale; Vincenzo Arena; Nico Pagano; Giacomo Rando; Fabio Romeo; Angelo E. Potenza; Alessandro Repici; Alberto Malesci; Silvio Danese

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 111 KB
Volume: 39
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200990022

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The cover image depicts human intestinal microvascular endothelial cells stained for ICAM‐1 after in vitro stimulation with the pro‐inflammatory cytokine TNF‐α. The image was taken from a recently‐published article by Scaldaferri et al. (Eur. J. Immunol. 2009. 39: 290–300), in which the authors demonstrate that stimulation with TNF‐α up‐regulates ICAM‐1 expression in human intestinal microvascular endothelial cells leading to increased recruitment of lymphocytes in the gut, a key pathogenic event in inflammatory bowel disease.

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