Cover Picture: Eur. J. Immunol. 11/09

✍ Scribed by Zala Jevnikar; Nataša Obermajer; Urša Pečar-Fonović; Adriana Karaoglanovic-Carmona; Janko Kos

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 187 KB
• Volume: 39
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.200990312

✦ Synopsis

Abstract

This issue's cover features a composite of images showing that cathepsin X promotes co‐localization of LFA‐1 and α‐actinin‐1 and are taken from Jevnikar et al. (pp. 3217–3227). In this article, the authors show that cleavage of the three C‐terminal amino acids of the β~2~ cytoplasmic tail of LFA‐1 by cathepsin X promotes binding of α‐actinin‐1 to LFA‐1; cathepsin X also enables LFA‐1 to transition from its high to intermediate affinity form for ICAM‐1. Together, the findings further our understanding of the mechanisms of T‐cell migration.