Cover Picture: Eur. J. Immunol. 4/09

✍ Scribed by Ashfaq Ghumra; Jianguo Shi; Richard S. Mcintosh; Ingunn B. Rasmussen; Ranveig Braathen; Finn-Eirik Johansen; Inger Sandlie; Patricia K. Mongini; Thomas Areschoug; Gunnar Lindahl; Melanie J. Lewis; Jenny M. Woof; Richard J. Pleass

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 242 KB
• Volume: 39
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.200990017

✦ Synopsis

Abstract

The cover image, provided by Ghumra et al. (pp. 1147–1156), shows two views of a molecular model of human dimeric IgA1 revealing residues predicted to be critical for interaction with human Fca/mR, a receptor with specificity for the Fc regions of IgA and IgM. The IgA heavy chains (tailpieces omitted) are shown in yellow, and the light chains in blue. The heavy chain residues proline 440 to phenylalanine 443 on the Ca3 domain of the IgA Fc region, implicated in hFca/mR interaction, are shown as red spheres. The J (joining) chain of the dimeric IgA is not included in the model, but the white dotted line in the lower view indicates a possible position.