✦ LIBER ✦

Cover Picture: Eur. J. Immunol. 2/12

✍ Scribed by Niki Tsakiri; Dimitrios Papadopoulos; Maria C. Denis; Dimos-Dimitrios Mitsikostas; George Kollias

Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 528 KB
Volume: 42
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.201290004

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The cover is based on a spinal cord histology section taken from a TNFR2^−/−^ mouse adoptively transferred with TNFR2^−/−^ Treg cells prior to immunization with MOG~35–55~ to induce EAE. The section is stained with Luxol Fast blue to detect demyelination; Luxol Fast Red, which detects inflammatory infiltration, is the counterstain. The image is taken from the article by Tsakiri et al. (pp. 403–412) in which it is shown that TNFR2 on non‐haematopoietic cells is necessary for Treg‐cell suppressive activity and repression of EAE development. The colour of the image has been digitally altered for the cover.

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