✦ LIBER ✦

Cover Picture: Eur. J. Immunol. 12/11

✍ Scribed by Jennifer L. Marshall; Yang Zhang; Lalit Pallan; Mei-Chi Hsu; Mahmood Khan; Adam F. Cunningham; Ian C. M. MacLennan; Kai-Michael Toellner

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 791 KB
Volume: 41
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.201190077

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The cover image shows immunohistological analysis of a spleen section from QMxB6 mice 96 hours after immunization with NP‐Ficoll. IgD staining (brown) determines the B‐cell follicles and NP‐staining (blue) the antibody‐producing cells; plasmablasts (dark blue regions) are present in the red pulp, and germinal centres (pale blue) can be seen in the follicles; the T zones (which lack B cells) remain unstained. The image is kindly provided by Jennifer Marshall and relates to the study Marshall et al. (pp. 3506–3512) in which it is shown that Ig class‐switch recombination during extrafollicular responses occurs at the B blast rather than the plasmablast stage.

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