Covalent binding of benzo[a]pyrene to DNA in fish liver
β Scribed by Usha Varanasi; John E. Stein; Tom Hom
- Book ID
- 118315335
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 488 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Individual metabolites of benzo (a)pyrene were isolated from rat liver microsomal incubation of the parent hydrocarbon, and subsequently bound to DNA in separate incubations with microsomes. Of the metabolites examined, by far the greatest binding resulted with 7,8βdihydroβ7,8βdihydroxy
The primary mode of non-covalent interaction of the strong carcinogen, benzo(a)pyrene diol epoxide, with DNA is through intercalation. It has variously been suggested that intercalative complexes may be prerequisite for either covalent binding or DNA-catalysed hydrolysis of the epoxide or both. Geac