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Costimulation of T-cell growth

✍ Scribed by Yang Liu; Peter S. Linsley

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
757 KB
Volume
4
Category
Article
ISSN
0952-7915

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✦ Synopsis

The specificity of T-cell recognition is dictated by the interaction of the T-cell receptor with MHC-peptide complexes. The biological consequences of such recognition is determined, however, by costimulatory pathway(s). Recent studies have led to the identification of receptor-counter-receptor pairs that may regulate T-cell costimulation.

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## Abstract Binding of the TNF family member, B cell activating factor (BAFF), to its receptor (BAFF‐R, TNFRSF13C) is required for generation and maintenance of mature B cells, but there are no data as to any role for the BAFF/BAFF‐R pathway in T cell functions. We report that the binding of BAFF t