Corrosion behavior and biocompatibility of nanostructured TiO2 film on Ti6Al4V

✍ Scribed by Ramji Karpagavalli; Anhong Zhou; Prithiviraj Chellamuthu; Kytai Nguyen

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 723 KB
• Volume: 83A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.31447

✦ Synopsis

Abstract

The corrosion behavior and cell adhesion property of nanostructured TiO~2~ films deposited electrolytically on Ti6Al4V were examined in the present in vitro study. The nanostructured TiO~2~ film deposition on Ti6Al4V was achieved via peroxoprecursors. SEM micrographs exhibit the formation of amorphous and crystallite TiO~2~ nanoparticles on Ti6Al4V before and after being annealed at 500°C. Corrosion behavior of TiO~2~‐deposited and uncoated Ti6Al4V was evaluated in freely aerated Hank's solution at 37°C by the measurement and analysis of open‐circuit potential variation with time, Tafel plots, and electrochemical impedance spectroscopy. The electrochemical results indicated that nano‐TiO~2~ coated Ti6Al4V showed a better corrosion resistance in simulated biofluid than uncoated Ti6Al4V. Rat bone cells and human aortic smooth muscle cells were grown on these substrates to study the cellular responses in vitro. The SEM images revealed enhanced cell adhesion, cell spreading, and proliferation on nano‐TiO~2~ coated Ti6Al4V compared to those grown on uncoated substrates for both cell lines. These results suggested that nanotopography produced by deposition of nanostructured TiO~2~ onto Ti alloy surfaces might enhance corrosion resistance, biocompatibility, and cell integration for implants made of Ti alloys. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007