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Correlations between behavioural and oxidative parameters in a rat quinolinic acid model of Huntington’s disease: Protective effect of melatonin

✍ Scribed by Antunes Wilhelm, Ethel; Ricardo Jesse, Cristiano; Folharini Bortolatto, Cristiani; Wayne Nogueira, Cristina

Book ID: 125450460
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 398 KB
Volume: 701
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2013.01.007

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm