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Correlation of YMDD mutation and breakthrough hepatitis with hepatitis B virus DNA and serum ALT during lamivudine treatment

โœ Scribed by Mariko Kobayashi; Fumitaka Suzuki; Norio Akuta; Hiromi Yatsuji; Tetsuya Hosaka; Hitomi Sezaki; Masahiro Kobayashi; Yusuke Kawamura; Yoshiyuki Suzuki; Yasuji Arase; Kenji Ikeda; Rie Mineta; Satomi Iwasaki; Sachiyo Watahiki; Hiromitsu Kumada


Book ID
118088188
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
377 KB
Volume
40
Category
Article
ISSN
1386-6346

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Lamivudine is an effective antiviral agent for the treatment of chronic type B hepatitis. Recent studies have shown the appearance of lamivudine resistant viruses with mutations at the tyrosine-methionine-aspartate-aspartate (YMDD) motif of the viral polymerase in hepatitis B virus (HBV) infected pa