Clinical outcomes of chronic hepatitis B patients with persistently detectable serum hepatitis B virus DNA during lamivudine therapy
✍ Scribed by Ji H Kim; Sang K Yu; Yeon S Seo; Hyung J Yim; Jong E Yeon; Jong J Park; Jae S Kim; Young T Bak; Chang H Lee; Kwan S Byun
- Book ID
- 108951377
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 231 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0815-9319
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This placebo controlled, double-blind study evaluated the efficacy and safety of lamivudine in patients with hepatitis B e antigen (HBeAg)-negative/hepatitis B virus (HBV) DNA-positive chronic hepatitis B. Patients were randomized to receive 100 mg lamivudine orally once daily for 52 weeks (n ؍ 60
## Abstract Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBV–DNA after a self‐limited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBV–DNA was tested
## Abstract We examined whether lamivudine treatment, in addition to the rapid decline of HBV serum DNA described in a large number of laboratories, causes changes in composition and amount of discernable circulating viral DNA and RNA. Nucleic acids were extracted from serial serum samples of a pat