Protein stability remains one of the main factors limiting the realization of the full potential of protein therapeutics. Poly(ethylene glycol) (PEG) conjugation to proteins has evolved into an important tool to overcome instability issues associated with proteins. The observed increase in thermodyn
Correlation of high-temperature stability of α-chymotrypsin with ‘salting-in’ properties of solution
✍ Scribed by Vladislav Yu. LEVITSKY; Anna A. PANOVA; Vadim V. MOZHAEV
- Book ID
- 115130991
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 679 KB
- Volume
- 219
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
a-Chymotrypsin has been modified with poly(ethylene glycols) and proxanols, block-copolymers of poly(propylene oxide) and poly(ethylene oxide). These conjugates were several-fold more thermostable and showed high catalytic activity at elevated concentrations of water-miscible organic cosolvents (alc
## Abstract The effect of pressure on the melting temperature of DNA (__Cl. perfringens__) has been examined in several concentrations of neutral salt by measurement of uv absorbance. The results indicate that the apparent transition volume increases as the salt concentration, and hence the melting