✦ LIBER ✦

Stability of α-chymotrypsin conjugated with poly (ethylene glycols) and proxanols at high temperature and in watercosolvent mixtures

✍ Scribed by Vadim V. Mozhaev; Elena V. Kudryashova; Nadezhda V. Efremova; Irina N. Topchieva

Book ID: 104645940
Publisher: Springer-Verlag
Year: 1996
Tongue: English
Weight: 503 KB
Volume: 10
Category: Article
ISSN: 0951-208X
DOI: 10.1007/bf00154670

No coin nor oath required. For personal study only.

✦ Synopsis

a-Chymotrypsin has been modified with poly(ethylene glycols) and proxanols, block-copolymers of poly(propylene oxide) and poly(ethylene oxide). These conjugates were several-fold more thermostable and showed high catalytic activity at elevated concentrations of water-miscible organic cosolvents (alcohols and dimethyl sulfoxide) which caused inactivation of free (non-modified) a-chymotrypsin.

📜 SIMILAR VOLUMES

Effect of the covalent modification with

Effect of the covalent modification with poly(ethylene glycol) on α-chymotrypsin stability upon encapsulation in poly(lactic-co-glycolic) microspheres

✍ Ingrid J. Castellanos; Wasfi Al-Azzam; Kai Griebenow 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 260 KB

The effectiveness of the covalent modification of a-chymotrypsin with methoxy poly(ethylene glycol) (PEG) to afford its stabilization during encapsulation in poly(lactic-co-glycolic) acid (PLGA) microspheres by a solid-in-oil-in-water method was investigated. a-Chymotrypsin was chemically modified w