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Correlation of cyclin D1 and cyclin D3 overexpression with the loss of PTEN expression in endometrial carcinoma

✍ Scribed by W. WU; B.M. SLOMOVITZ; P.T. SOLIMAN; K.M. SCHMELER; J. CELESTINO; M.R. MILAM; K.H. LU

Book ID: 109085856
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 164 KB
Volume: 16
Category: Article
ISSN: 1048-891X
DOI: 10.1111/j.1525-1438.2006.00642.x

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## Background: In the normal cell cycle, tumor suppressor gene products (p53) and cyclin (cyclin d1) cooperate. abnormalities in the cooperation of these factors may result in malignant transformation of the cell. mutant p53 protein overexpression is defined in many human cancers, including endomet