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Cyclin D1 overexpression in invasive breast cancers: correlation with cyclin-dependent kinase 4 and oestrogen receptor overexpression, and lack of correlation with mitotic activity

✍ Scribed by Yasuko Takano; Haruyuki Takenaka; Yo Kato; Mitsunobu Masuda; Tetsuo Mikami; Makoto Saegusa; Isao Okayasu


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
304 KB
Volume
125
Category
Article
ISSN
1432-1335

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␀-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the n