## Abstract In an effort to develop robust Chinese Hamster Ovary host cell lines, a variety of antiβapoptotic genes were overβexpressed, either singly or in combination, followed by screening of transfectants for improved cell growth, extended longevity, reduced caspase 3/7 activity, and enhanced m
β¦ LIBER β¦
Correlation of antibody production rate with glucose and lactate metabolism in Chinese hamster ovary cells
β Scribed by Fei Chen; Zhaoyang Ye; Liang Zhao; Xuping Liu; Li Fan; Wen-Song Tan
- Book ID
- 106365235
- Publisher
- Springer Netherlands
- Year
- 2011
- Tongue
- English
- Weight
- 311 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0141-5492
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## Abstract Mammalian cells are used for the production of numerous biologics including monoclonal antibodies. Unfortunately, mammalian cells can lose viability at later stages in the cell culture process. In this study, the effects of expressing the antiβapoptosis genes, __E1Bβ19K__ and __Aven__,