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Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

✍ Scribed by Brian S. Majors; Michael J. Betenbaugh; Nels E. Pederson; Gisela G. Chiang

Publisher: American Institute of Chemical Engineers
Year: 2009
Tongue: English
Weight: 462 KB
Volume: 25
Category: Article
ISSN: 8756-7938
DOI: 10.1002/btpr.192

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## Abstract Mammalian cells are used for the production of numerous biologics including monoclonal antibodies. Unfortunately, mammalian cells can lose viability at later stages in the cell culture process. In this study, the effects of expressing the anti‐apoptosis genes, __E1B‐19K__ and __Aven__,